I.c.f. Tris nac 120 ml - sterile solution for dogs & cats

Product Description

Tris-NAC

Description

Sterile solution.
Tris-EDTA + N-Acetyl Cysteine ​​(NAC) buffer with high hygienic strength for dogs and cats.
Tris-EDTA (Ethylene Diammine Tetracetic Acid) has bactericidal activity on non-growing bacteria located within the biofilm (Ciofu et al, 2017); in association with Tromethamine (Tris) it damages the walls of bacterial cells and increases penetration into bacterial membranes; it is well tolerated and non-ototoxic; it acts in synergy with chlorhexidine (Guardabassi et al, 2010). Recently, an in vitro study has shown that Tris-EDTA is a more effective support for the prevention of bacterial infections (Guardabassi et al, 2010). that is effective in the treatment of chronic cases of Pseudomonas otitis media with the presence of potential biofilms combined with antibiotics (Pye et al, 2014).
NAC is an N-acetylated derivative of the amino acid cysteine. It has a mucolytic action, thus disrupting the production of exopolysaccharides, thus weakening the EPS matrix. It has recently been used in eight clinical studies as an adjuvant treatment to destroy mature biofilm and prevent its formation and has demonstrated an excellent safety and efficacy profile.
The combination of Tris-EDTA and NAC on the skin and in the ear before the application of topical products such as chlorhexidine, antibiotics, and synthetic antimicrobial peptides therefore allows for an increase in the permeability of the mature biofilm and, consequently, its disintegration, effectively helping to overcome the problem of resistance to classic antibacterial therapeutic approaches.

Directions for use

1. Apply pressure to the top of the bottle until the capsule breaks completely.
2. Shake the bottle.
3. Use the syringe inside the package to draw up the amount to be used, according to the instructions of your veterinarian.
In the ear canal: irrigate adequately and massage at the base of the ear.
On the skin: irrigate until the affected area is completely soaked.
Repeat the treatment as needed or as directed by your veterinarian.

Format

120 ml bottle.