External antiparasitic suitable for dogs over 40 kg.
Indications
Amflee Combo by Krka is a veterinary medicinal product for dogs weighing over 40 kg for the treatment of infestations by fleas alone or in combination with ticks and/or biting lice. The insecticidal efficacy against new infestations with adult fleas persists for 8 weeks. It prevents the multiplication of fleas by inhibiting the development of eggs, larvae and pupae from eggs laid by adult fleas for 8 weeks after application. With regard to infestations by ticks (Ixodes ricinus, Dermacentor variabilis, Dermacentor reticulatus, Rhipicephalus sanguineus), the product has persistent acaricidal efficacy for up to 4 weeks. The product can be used in combination with other products. be used as part of the treatment strategy for the control of Flea Allergy Dermatitis (FAD), where it has been previously diagnosed by a veterinarian.
Composition
Active ingredients
Each 4.02 ml pipette contains: fipronil 402 mg, S-methoprene 361.8 mg.
Excipients
Butylhydroxyanisole (E320), Butylhydroxytoluene (E321), Povidone (K25), Polysorbate 80, Ethanol 96%, Diethylene glycol monoethyl ether.
Directions for use and Dosage
For external use only, spot-on use. Administer by topical application to the skin: one pipette of 4.02 ml (402 mg fipronil + 361.8 mg S-methoprene) per dog weighing over 40 kg. This corresponds to the minimum recommended dose of 6.7 mg/kg fipronil and 6 mg/kg S-methoprene for topical administration to the skin. In the absence of safety studies, the minimum treatment interval is 4 weeks.
How to use:
- Remove the pipette from the pouch;
- Hold the pipette upright, twist and remove the cap;
- Turn the cap upside down and replace it on the other end of the pipette;
- Press and twist the cap to break the seal, then remove the cap from the pipette;
- Part the animal's hair on the animal's back at the base of the neck in front of the shoulder blades until the skin is visible;
- Place the tip of the pipette on the skin and squeeze the pipette several times to empty the contents completely and directly onto the skin in one spot;
- Temporary changes to the hair at the application site (clumps/greasiness of the hair) may be observed.
Warnings
Bathing/immersion in water within 2 days of product application and bathing more frequently than once a week should be avoided, as no studies have been performed to investigate how these affect the efficacy of the product. Emollient shampoos may be used before treatment, but the duration of flea protection is reduced by approximately 5 weeks when used weekly after product application. Weekly bathing with a 2% chlorhexidine medicated shampoo did not affect flea efficacy during a 6-week study. Attachment of single ticks may occur. For this reason, transmission of infectious diseases cannot be completely ruled out under favorable conditions. Fleas on animals often infest bedding, blankets, and other areas where the animal rests, such as carpets and upholstery. In the event of massive infestations and at the start of control measures, these should be treated with a suitable insecticide and regularly vacuumed. Avoid contact with the animal's eyes. It is important to ensure the product is applied to an area where animals cannot lick it, and to ensure that animals do not lick each other following treatment.
Special precautions to be taken by the person administering the veterinary medicinal product to animals: This product may cause irritation to mucous membranes, skin, and eyes. Therefore, contact between the product and the mouth, skin, and eyes should be avoided. People with known hypersensitivity to insecticides or alcohol should avoid contact with the product. Avoid allowing the contents to come into contact with fingers. If this happens, wash your hands immediately with soap and water. In case of accidental contact with eyes, rinse immediately with plenty of clean water. Wash hands after use. In case of accidental ingestion, seek medical advice immediately and show the package leaflet or label to the doctor. Do not smoke, drink, or eat during application. Treated animals should not be handled until the application site is dry, and children should not be allowed to play with treated animals until the application site is dry. It is therefore recommended not to treat animals during the day, but in the evening, and not to allow recently treated animals to sleep with their owners, especially children. Other precautions: Dogs should not be allowed to swim in water for 2 days after application.
Contraindications
In the absence of available data, the product should not be used on puppies under 8 weeks of age and/or weighing less than 2 kg. Do not use in sick (e.g., systemic disease, fever) or convalescent animals. Do not use in rabbits, due to the risk of adverse reactions or even death. This product is specifically developed for dogs. Do not use in cats and ferrets, as overdose may occur. Do not use in case of hypersensitivity to the active substance or to any of the excipients.
Undesirable effects
Among the extremely rare suspected adverse reactions, transient skin reactions at the application site (skin discoloration, local alopecia, pruritus, erythema) and general pruritus or alopecia have been reported after use. Hypersalivation, reversible neurological symptoms (hyperesthesia, depression, nervous symptoms), vomiting, and/or respiratory symptoms have also been observed after use. If the animal licks itself, a brief period of hypersalivation may be observed due to the nature of the excipients. Do not overdose.
Pregnancy and breastfeeding
The product can be used during pregnancy and breastfeeding.
Storage
Store in the original package to protect from light and moisture. This veterinary medicinal product does not require any special temperature storage conditions.
Format
3 Pipettes
Product Code:FRCM201802
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