Bayer italia Advantix spot on for dogs from 40 to 60 kg - 6 6 ml pipettes

Product Description

Veterinary drug for the treatment and prevention of fleas for dogs from 40 to 60 kg.

Indications

Advantix Spot On for dogs from 40 to 60 kg from Bayer is a veterinary drug for the treatment and prevention of flea infestations (Ctenocephalides canis, Ctenocephalides felis). Fleas on dogs are killed within one day of treatment, one treatment prevents further flea infestation for four weeks. The product can be used as part of a treatment strategy for flea allergy dermatitis (FAD). For the treatment of lice (Trichod ectes canis). The product has persistent acaricidal and repellent efficacy against tick infestations (Rhipicephalus sanguineus and Ixodes ricinus for four weeks, and Dermacentor reticulatus for three weeks). Through its repellent and knockdown action on the Rhipicephalus sanguineus tick vector, the product reduces the likelihood of transmission of the Ehrlichia canis pathogen, thereby reducing the risk of canine ehrlichiosis. The risk reduction was demonstrated in studies starting from the third day after application of the product and persists for 4 weeks. Ticks already present on the dog may not be killed within two days after treatment and may remain attached and visible. It is therefore recommended to remove any ticks already present on the dog at the time of treatment to prevent them from attaching and taking a blood meal. One treatment provides repellent (anti-feeding) activity against sand flies (Phlebotomus papatasi for two weeks and Phlebotomus pernic iosus for three weeks), mosquitoes (Aedes aegypti for two weeks and Culex pipiens for four weeks) and horse flies (Stomoxys calcitrans) for four weeks.

Composition

Active substances

Each 6.0 ml pipette contains: active substances: imidacloprid: 60 0.0 mg; permethrin (40/60): 3000.0 mg.

Excipients

Excipient(s): butylhydroxytoluene (E321): 6.0 mg. Butylated hydroxytoluene (E321), N-methylpyrrolidone, medium-chain triglycerides, citric acid (E330; for pH adjustment).

Directions for use and Dosage

For cutaneous use only. Apply only to intact skin. The minimum recommended dose is: 10 mg/kg body weight (bw) of imidacloprid and 50 mg/kg body weight (bw) of permethrin.

For dogs >60 kg, the appropriate combination with other pipette strengths should be used.

To reduce reinfestation due to the appearance of new fleas, it is recommended to treat all dogs in the household. Other animals living in the same household should be treated with a suitable product. To further help reduce the environmental threat, the additional use of a suitable environmental treatment against adult fleas and their developing stages is recommended. The product remains effective if the animal gets wet. However, intense and prolonged exposure to water should be avoided. Frequent exposure to water may reduce the effectiveness of the product. In these cases, do not repeat the treatment more frequently than once a week. If your dog requires shampooing, it is best to do so before applying Advantix or at least two weeks after application to optimize the product's effectiveness. In case of lice infestation, a further veterinary visit is recommended 30 days after treatment, because Some animals may require a second treatment.

• Remove one pipette from the package.
• Holding the pipette upright, twist and remove the cap.
• Turn the cap back and replace the opposite end on the pipette.
• Twist the cap to break the seal and then remove the cap from the pipette.
• With the dog standing still on all fours, the entire contents of the Advantix pipette should be applied equally to four spots on the top of the back from the shoulders to the base of the tail.
• At each spot, part the coat until the skin is visible.
• Place the tip of the pipette on the skin and squeeze gently to empty some of the solution onto the skin.
• Do not apply too much solution to any spot as this may cause irritation. that some of it runs down the dog's flanks.

Warnings

Single ticks may attach or single sandflies or mosquitoes may bite. For this reason, if conditions are unfavorable, transmission of infectious diseases by these parasites cannot be completely ruled out. It is recommended to apply the treatment at least 3 days before expected exposure to E. canis. With regard to E. canis, studies have shown a reduced risk of canine ehrlichiosis in dogs exposed to Rhipicephalus sanguineus ticks infected with E. canis from 3 days following application of the product and persisting for 4 weeks.

Special precautions for use in animals: Care should be taken to avoid contact of the contents of the pipette with the eyes or mouth of treated dogs. In particular, oral ingestion due to licking of the application site by treated animals or by animals in contact with them must be prevented. Do not use on cats. This product is extremely toxic to cats and could be fatal due to the unique physiology of cats, which are unable to metabolize certain compounds, including permethrin. To prevent cats from being accidentally exposed to the product, keep treated dogs away from cats after treatment and until the application site has dried. It is important to ensure that cats do not lick the application site of a dog treated with this product. If this occurs, seek immediate veterinary advice. Consult your veterinarian before using the product on sick or debilitated dogs.

Special precautions to be taken by the person administering the veterinary medicinal product to animals:

Avoid contact of the product with skin, eyes, or mouth. Do not eat, drink, or smoke during application. Wash hands thoroughly after use. In case of accidental spillage on the skin, wash immediately with soap and water. People with known skin sensitivity may be particularly sensitive to this product. The predominant clinical symptoms, which may occur in extremely rare cases, are transient sensory irritation of the skin such as tingling, burning, or numbness. If the product accidentally gets into the eyes, they should be rinsed thoroughly with water. If skin or eye irritation persists, seek medical advice immediately and show the package leaflet or label. Do not ingest. In case of accidental ingestion, seek medical advice immediately and show the package leaflet or label. Treated dogs should not be handled, especially by children, until the application site is dry. This can be ensured, for example, by treating dogs in the evening. Recently treated dogs should not be allowed to sleep with their owners, especially children. To prevent children from having access to the pipettes, keep the pipette in the original packaging until ready for use and discard used pipettes immediately.

Other precautions: Since the product is hazardous to aquatic organisms, under no circumstances should treated dogs be allowed to enter any type of surface water for at least 48 hours after treatment. The solvent contained in Advantix Spot-on may stain some materials, including leather, fabric, plastic, and polished surfaces. Allow the application site to dry before allowing contact with such materials. No adverse clinical signs were observed in puppies or healthy adult dogs exposed to a 5x overdose, or in puppies whose mothers were treated with a 3x overdose of the product. Main incompatibilities: none known.

Contraindications

In the absence of available data, the product should not be used on puppies under 7 weeks of age or 40 kg in weight. Do not use in cases of hypersensitivity to the active substances or to any of the excipients. Do not use on cats.

Side effects

On very rare occasions, dogs may experience transient skin sensitivity (increased local itching, scratching and rubbing, hair loss and redness at the application site) or lethargy which generally resolve spontaneously. In very rare cases, dogs may show behavioral changes (agitation, restlessness, whining or rolling movements), gastrointestinal symptoms (vomiting, diarrhea, hypersalivation, decreased appetite) and neurological signs such as staggering movement and twitching in dogs sensitive to permethrin. These signs are generally transient and resolve spontaneously. Poisoning following inadvertent oral ingestion in dogs is unlikely, although this may occur very rarely. If this occurs, neurological signs such as tremors and lethargy may occur. Treatment should be symptomatic. There are no known specific antidotes. The frequency of adverse reactions is defined using the following conventions: very common (more than 1 in 10 animals treated displaying adverse reactions); common (more than 1 but less than 10 animals in 100 animals treated); uncommon (more than 1 but less than 10 animals in 1,000 animals treated); rare (more than 1 but less than 10 animals in 10,000 animals treated

Pregnancy and lactation

Can be used during pregnancy and lactation.

Storage

Do not freeze. After opening the foil pouch, store in a dry place at a temperature not exceeding 30 degrees C. Shelf life of the product in the foil pouch: 3 years. Shelf life of the product after opening the foil pouch: 12 months (all pipettes must be used within 12 months after opening the foil pouch or before the expiry date printed on the pipette, whichever is shorter). Shelf life of the opened pipette: After opening, the entire contents of the pipette must be applied to the animal's skin.

Format

3 Pipettes from 6 ml