Nicorette 2 mg to quit smoking 105 chewing gums

Product Description

Chewing Gum

NICORETTE 2 mg medicated chewing gum. One gum contains: active ingredient: 10 mg of nicotine resin complex containing 20% ​​nicotine, corresponding to 2 mg of nicotine.

Excipients: One 2 mg gum contains: anhydrous sodium carbonate, sodium bicarbonate, chewing gum base, sorbitol powder, 70% sorbitol solution, mint and fruit flavors, 85% glycerin solution.

Therapeutic indications: Treatment for smoking cessation.

 Contraindications: Nicorette should not be administered to non-smokers or to patients with known hypersensitivity to nicotine. In case of recent myocardial infarction; unstable or worsening angina pectoris; Prinzmetal's angina; severe cardiac arrhythmia; acute stroke.

 Dosage: Children and adolescents: NICORETTE chewing gum should not be administered to persons under 18 years of age without medical advice. Adults and the elderly: The dosage of NICORETTE depends on the number of cigarettes normally consumed by the individual smoker. It is advisable to start with the 2 mg preparation and, as needed, identify the optimal dosage and the number of gums to chew during the day. If 15 2 mg gums per day are not sufficient, as for example in heavy smokers (more than 20 cigarettes per day), it is preferable to use NICORETTE 4 mg chewable gums, or two 2 mg gums at the same time. Chew one gum each time you feel the urge to smoke. It is important to CHEW VERY SLOWLY FOR AT LEAST 30 MINUTES to release the nicotine. Chewing too quickly causes the nicotine to be absorbed too quickly: to avoid this, it is recommended to stop chewing occasionally. Do not use more than 15 4 mg gums per day. The recommended duration of treatment is 3 months. After this period, the daily dose should be gradually reduced. Once it has dropped to 1-2 gums, it is recommended to try to stop using NICORETTE completely. However, it is advisable to keep some spare gum on hand in case the cravings suddenly return. NICORETTE chewing gum is also easy to handle for diabetics because it contains no sucrose or glucose. It is not advisable to continue treatment for more than 12 months.

Caution: Do not exceed the recommended dose. Use NICORETTE chewable gum as directed above when you feel the urge to smoke, in order to maintain complete abstinence from smoking. The number of gums used must be sufficient to cover the nicotine requirement. For most smokers, 10 2 mg gums per day are usually sufficient.

 Warnings and precautions: The cardiovascular effects of nicotine may be risky in patients with severe cardiovascular disease (peripheral occlusive arterial disease, cerebrovascular disease, unstable angina pectoris, and heart failure), vasospasms, uncontrolled hypertension, severe hepatic and/or renal insufficiency, and active duodenal and gastric ulcers. NICORETTE should be used with caution and under close medical supervision by patients with diabetes mellitus, hyperthyroidism, or pheochromocytoma, since nicotine causes the release of catecholamines from the adrenal glands. However, using NICORETTE is less risky than smoking. The product should be kept out of reach of children, as with cigarettes, cigars, and tobacco. Smokers with dentures may have difficulty chewing NICORETTE gum; however, the special formulation of the gum minimizes this inconvenience. Smoking and concomitant use of nicotine replacement therapy (NRT). When using nicotine replacement therapy products to reduce smoking, the nicotine released from cigarettes is also present in the body. It is unclear whether the nicotine released from cigarettes influences the elimination of nicotine provided by replacement therapy products, or vice versa. Although it has been reported that nicotine is eliminated more rapidly in smokers than in nonsmokers, suggesting that nicotine itself promotes its own elimination, a more detailed study has shown that the opposite is also true. Another study showed that cotinine, the main metabolite of nicotine produced by smoking, did not increase or decrease nicotine elimination. In a more direct test conducted on the same subjects, the elimination of intravenously administered nicotine was 36% slower during a short period of smoking compared to a short period of abstinence. The product contains sodium salts: use with caution in subjects on a low-sodium diet. The mint-free chewing gum contains sorbitol: use with caution in cases of hereditary fructose intolerance; it may cause stomach problems and diarrhea.

Interactions: Smoking is associated with an increase in CYP1A2 enzyme activity. After smoking cessation, a reduction in the clearance of substrates of this enzyme may occur. This may lead to an increase in plasma levels of some potentially clinically important drugs with a narrow therapeutic index, such as theophylline, tacrine, and clozapine. Smoking cessation may also increase the concentration of other drugs partially metabolized by the CYP1A2 enzyme, such as imipramine, olanzapine, clomipramine, and fluvoxamine, although data are limited and the possible clinical significance is unknown. Limited data also indicate that smoking may induce the metabolism of flecainide and pentazocine.

 Side effects: The most frequently reported side effects in clinical trials are similar to those that can occur when smoking and may be caused by using more NICORETTE than the usual amount of cigarettes. These effects may include: cough, headache, mouth and throat irritation, nasal congestion, ulcerative ulcers, sore throat, anxiety, depression, malaise, vomiting, dry mouth, heartburn, joint pain, diarrhea, bloating, allergy, shortness of breath, thirst, and hiccups. Some symptoms, such as dizziness, headache, and insomnia, may be related to withdrawal symptoms associated with smoking cessation and may also occur with insufficient use of NICORETTE.

Pregnancy and breastfeeding: Pregnancy. Only if the pregnant woman continues to smoke can the use of NICORETTE be justified, as its use may carry potential risks. Nicotine reaches the fetus and affects its cardiorespiratory system. The effect is dose-dependent. Therefore, pregnant smokers are advised to stop smoking completely without undertaking nicotine replacement therapy. The risk of continuing to smoke could cause greater harm to the fetus than that caused by the use of nicotine replacement therapy, according to a controlled smoking cessation program. Breastfeeding. Nicotine passes freely into breast milk in amounts that can have harmful effects on the infant. This also occurs with the use of drugs containing nicotine, at the recommended therapeutic doses.