Tachipirina adults 1000 mg - analgesic antipyretic 10 suppository

Product Description

Analgesic and antipyretic drug based on paracetamol.

Indications

Tachipirina 1000 suppositories for adults is a drug useful as both an antipyretic and an analgesic.

As an antipyretic, Tachipirina 1000 mg suppositories can be used in the symptomatic treatment of febrile conditions due to influenza, respiratory conditions and exanthematous diseases.

As an analgesic, this drug can be used in the symptomatic treatment of febrile conditions due to influenza, respiratory conditions and exanthematous diseases. It can be administered to treat mild pain conditions such as headaches, myalgia or neuralgia.

Composition

Tachipirina 1000 mg suppositories for adults contain:

Active ingredient: paracetamol 1000 mg.
Excipients: solid semi-synthetic glycerides.

Dosage and method of use

The maximum dose of paracetamol that can be administered is 1000 mg. The recommended dose to be administered rectally in adults is 4000 mg per day.

• Children weighing between 41 and 50 kg (approximately between 12 and 15 years): 1 suppository at a time, to be repeated if necessary after 8 hours, without exceeding 3 administrations per day.
• Children weighing more than 50 kg (approximately over 15 years) and adults: 1 suppository at a time, to be repeated if necessary after 6 hours, without exceeding 4 administrations per day. The doctor must evaluate the need for treatments for more than 3 consecutive days.

Tachipirina in Pregnancy and Breastfeeding

The use of Tachipirina suppositories during pregnancy or during breastfeeding, despite clinical studies having not highlighted any particular contraindications or risks, is contraindicated in women with a history of breastfeeding. Since it has caused adverse effects in either the mother or the child, it is recommended only in cases of real need and under the direct supervision of a doctor.

Warnings and precautions

In rare cases of allergic reactions, administration should be suspended and appropriate treatment should be initiated.
Use with caution in cases of chronic alcoholism, excessive alcohol intake (3 or more alcoholic drinks per day), anorexia, bulimia or cachexia, chronic malnutrition (low hepatic glutathione reserves), dehydration, hypovolemia.
Paracetamol should be administered with caution to patients with mild to moderate hepatocellular insufficiency (including Gilbert's syndrome), severe hepatic insufficiency (Child-Pugh>9), acute hepatitis, concomitant treatment with drugs that alter liver function, glucose-6-phosphate dehydrogenase deficiency, hemolytic anemia.
High or prolonged doses of the product can cause alterations to the kidneys and blood, even serious ones, therefore, administration to patients with renal insufficiency should be carried out only if truly necessary and under direct medical supervision. In case of prolonged use, it is advisable to monitor liver and renal function and blood count.
During treatment with paracetamol, before taking any other medication, check that it does not contain the same active ingredient, since if paracetamol is taken in high doses, serious adverse reactions can occur. Contact your doctor before combining any other medication.

Interactions

Concomitant use of paracetamol and chloramphenicol may increase the half-life of chloramphenicol, with the risk of increasing its toxicity. Concomitant use of paracetamol (4 g daily for at least 4 days) with oral anticoagulants may cause slight changes in INR values. In these cases, more frequent monitoring of INR values ​​should be conducted during concomitant use and after its discontinuation. Use with extreme caution and under close supervision during chronic treatment with drugs that can induce hepatic monooxygenases or in case of exposure to substances that can have this effect (for example, rifampicin, cimetidine, antiepileptics such as glutethimide, phenobarbital, carbamazepine). The same applies in cases of alcoholism and in patients treated with zidovudine. Paracetamol administration may interfere with the determination of uric acid levels (using the phosphotungstic acid method) and blood glucose levels (using the glucose-oxidase-peroxidase method).

Contraindications

• Hypersensitivity to the active substance or to any of the excipients.
• Patients suffering from severe haemolytic anaemia (this contraindication does not apply to the 500 mg oral formulations).
• Severe hepatocellular insufficiency (this contraindication does not apply to the 500 mg oral formulations).

Undesirable effects

The following are the undesirable effects of paracetamol organised according to the MedDRA system organ class. There are insufficient data to establish the frequency of the individual effects listed.

Blood and lymphatic system disorders: Thrombocytopenia, leukopenia, anaemia, agranulocytosis.
Immune system disorders: Hypersensitivity reactions (urticaria, laryngeal edema, angioedema, anaphylactic shock).
Nervous system disorders: Dizziness.
Gastrointestinal disorders: Gastrointestinal reaction.
Hepatobiliary disorders: Abnormal liver function, hepatitis.
Skin and subcutaneous tissue disorders: Erythema multiforme, Stevens-Johnson syndrome, epidermal necrolysis, rash.
Renal and urinary disorders: Acute renal failure, interstitial nephritis, hematuria, anuria.

Furthermore, very rare cases of serious skin reactions have been reported.

Format

Pack containing 10 Tachipirina 1000 mg suppositories