Pevaryl 1% cream - treatment of cutaneous mycoses 30 g

Product Description

Topical cream indicated for the treatment of fungal infections

Indications

Pevaryl is an antifungal medicine for the local treatment of infections caused by some fungi and yeasts, including suspected concomitant infections caused by Gram-positive bacteria and Pityriasis Versicolor.

Composition

Pevaryl 1% cream 100 g of cream contain: active ingredient: econazole nitrate 1.0 g

Excipients

Cream Excipients: mixture of stearic acid esters with glycols, mixture of fatty acids with polyethylene glycol, vaseline oil, butylhydroxyanisole, perfume n.4074, benzoic acid, purified water.

Contraindications

Pevaryl is contraindicated in patients with known hypersensitivity to the active substance or to any of the excipients. Pevaryl is indicated for external use only. Pevaryl is not indicated for ophthalmic or oral use.
If allergic reactions or irritation occur, stop treatment and contact your doctor. The use of topical products, especially if prolonged, may give rise to sensitization phenomena. If this occurs, stop treatment and contact your doctor.
In case of particularly intense local reactions, it is necessary to stop treatment and consult your doctor.

Side effects

Common side effects (may affect up to 1 in 10 people) include:
• Itching
• Burning sensation of the skin
• Pain

Dosage

Pevaryl should be applied to the infected skin areas with a light massage twice a day, morning and evening. The usual duration of treatment is 2 to 4 weeks. If no improvement in symptoms is noted after 4 weeks, the treatment should be reevaluated. Intertriginous spaces (e.g., interdigital spaces of the foot, buttock folds) in the moist state must be cleansed with gauze before applying PEVARYL. In the case of intertrigo, the use of Pevaryl skin powder may be useful.

Warnings and precautions

All pharmaceutical forms of PEVARYL are indicated for external use only. PEVARYL is not for ophthalmic or oral use. In case of sensitization or irritation, discontinue use of the product. Econazole nitrate powder contains talc. Avoid inhalation to prevent airway irritation, especially in children and infants. Spray applications should be done while avoiding inhalation and excessive or improper use.

Interactions

Econazole is a known inhibitor of cytochromes CYP3A4 and CYP2C9. Despite limited systemic availability after cutaneous application, clinically relevant interactions with other medicinal products may occur, and some have been reported in patients treated with oral anticoagulants, such as warfarin and acenocoumarol. Caution should be exercised in patients treated with oral anticoagulants, and the INR should be monitored more frequently. Dosage adjustment of the oral anticoagulant may be necessary during treatment with econazole and after its discontinuation.

Format

30g tube