Luan 1% surgical gel - anesthetic 100%

Product Description

Composition

LUAN 2.5% gel 100 g contain: Lidocaine hydrochloride 2.5 g. Excipients: methyl p-hydroxybenzoate, ethyl p-hydroxybenzoate, propyl p-hydroxybenzoate, sodium benzoate For the full list of excipients, see section 6.1 LUAN 1% gel 100 g contain: Lidocaine hydrochloride 1 g Excipients: methyl p-hydroxybenzoate, ethyl p-hydroxybenzoate, propyl p-hydroxybenzoate, sodium benzoate For the full list of excipients, see section 6.1

Excipients

LUAN 2.5% gel Excipients: sodium carmellose, glycerol, methyl p-hydroxybenzoate, ethyl p-hydroxybenzoate, propyl p-hydroxybenzoate, sodium benzoate, purified water. LUAN 1% gel Excipients: sodium carmellose, glycerol, methyl p-hydroxybenzoate, ethyl p-hydroxybenzoate, propyl p-hydroxybenzoate, sodium benzoate, purified water.

Therapeutic indications

- LUAN 2.5% gel: Facilitates endourethral maneuvers (introduction of catheters, dilations, cystoscopy, etc.) by combining the lubricating and anesthetic action. - LUAN 1% gel: Esophagoscopic intubations and for curative anesthesia, pharyngoscopy, tracheo-bronchoscopies, gastroscopy and rectoscopy, and in all endoscopic indications of an exploratory and curative nature. The product, combining lubricating and anesthetic action, helps prevent spastic reactions and reflexes from the mucous membranes with which the instruments come into contact during endoscopic procedures.

Contraindications

Hypersensitivity to amide-type local anesthetics or to any of the excipients.

Luan Gel Dosage

LUAN 2.5% gel: Push the ointment directly into the urethra by squeezing the tube and simultaneously massaging the posterior urethra, applying urethral forceps for 10 minutes, after which the desired endourethral maneuvers can be performed. The contents of the tube are sufficient to completely fill the urethra. To facilitate the introduction of the medication and eliminate the pain that may be caused by the contact of the metal tip of the tube with particularly painful areas, the package is supplied with a plastic extension to be screwed onto the tube itself at the time of use. LUAN 1% gel Carefully spread a layer of product on the instrument before inserting it. The neutrality of the vehicle of both product formulations, its complete solubility in water and the absence of fatty substances mean that, even with continued use of LUAN, the lenses of the instruments used for the various types of intubation do not fog up and their rubber parts do not deteriorate. LUAN must be used with caution in patients with severely damaged mucous membranes and sepsis in the area to which it is to be applied. Exercise caution in children, the elderly and seriously ill patients (see also section 4.4 Special warnings and precautions for use).

Warnings and precautions

The efficacy and safety of lidocaine depend on correct dosage and application technique. Therefore, the smallest amount of the preparation sufficient to achieve the desired effect should be used and application for very prolonged periods should be avoided. LUAN should be used with caution in patients with severely damaged mucous membranes or inflammatory processes or sepsis in the area where it is to be applied, as excessive absorption of the active ingredient may occur. High levels of lidocaine absorption can cause serious reactions affecting the central nervous system and the cardiovascular system, particularly in children, the elderly, and debilitated subjects (see section 4.2). Topical products, especially if used for a prolonged or repeated period, may give rise to sensitization phenomena. In this case, treatment must be discontinued and appropriate therapy instituted. Information on some excipients of LUAN The medicine contains sodium benzoate: it may be mildly irritating to the skin, eyes, and mucous membranes. The medicine contains parahydroxybenzoates: it may cause allergic reactions, even delayed.

Interactions

Propranolol prolongs the plasma half-life of lidocaine. Cimetidine may increase plasma levels of lidocaine.

Undesirable effects

Local hypersensitivity reactions characterized by pain, burning, and itching may occur. Systemic reactions are generally rare. However, hypersensitivity reactions up to anaphylactic shock may occur. In the presence of irritated or damaged skin, the risk of systemic absorption and toxicity increases. Treatment of large areas and/or the use of high doses or an increase in body temperature may increase the risk of systemic absorption and a potential increase in toxicity.

Pregnancy and breastfeeding

Studies in rats and rabbits have not revealed any risks for the fetus. However, its safety in humans has not been established. This should be kept in mind before administering to pregnant women, especially in the early stages. Since Lidocaine is distributed in breast milk. The use of topical preparations, especially if applied to the tracheobronchial mucosa, should be used with caution in breastfeeding women.