Aspirin c 400 + 240 mg - anti-inflammatory 40 effervescent tablets with vitamin c

Product Description

Aspirin C 400 mg + 240 mg effervescent tablets with Vitamin C

Thanks to its triple effect (antipyretic, anti-inflammatory, analgesic), it works against: flu-like pain, sore throat, fever.
Vitamin C has a positive effect on the immune system. Vitamin C fights free radicals produced during inflammation.

One tablet contains: active ingredients: acetylsalicylic acid 400 mg, ascorbic acid (Vitamin C) 240 mg

Excipients

Monosodium citrate, sodium bicarbonate, sodium carbonate, anhydrous citric acid.

Therapeutic indications

Symptomatic treatment of feverish states and flu and cold syndromes. Symptomatic treatment of headache and toothache, neuralgia, menstrual pain, rheumatic and muscle pain.

Contraindications

Aspirin effervescent tablets with vitamin C are contraindicated in case of: hypersensitivity to the active ingredients (acetylsalicylic acid and ascorbic acid), to other analgesics (painkillers), antipyretics (antipyretics), nonsteroidal anti-inflammatory drugs (NSAIDs) or to any of the excipients; gastroduodenal ulcer; haemorrhagic diathesis; severe renal, cardiac or hepatic insufficiency; glucose-6-phosphate dehydrogenase deficiency (G6PD/favism); concomitant treatment with methotrexate (at doses of 15 mg/week or more) or with warfarin; history of asthma induced by the administration of salicylates or substances with similar activity, especially nonsteroidal anti-inflammatory drugs; last trimester of pregnancy and breastfeeding; children and adolescents under 16 years of age.

Dosage

1–2 tablets as a single dose, repeating, if necessary, the dose at intervals of 4–8 hours up to 3–4 times a day. Aspirin C must always be dissolved before use (1 tablet in half a glass of water). The product is for use by adults only. Always use the lowest effective dose and increase it only if it is not sufficient to relieve symptoms (pain and fever). Do not exceed the recommended doses: elderly patients in particular should stick to the minimum doses indicated above. Those most at risk of serious side effects, who can use the medicine only if prescribed by a doctor, must carefully follow the instructions. Use the medicine for the shortest possible period. Do not take the product for more than 3-5 days without consulting your doctor. Consult your doctor if symptoms persist. Take the medicine preferably after main meals or, in any case, on a full stomach.

Paediatric population: Aspirin effervescent tablets with vitamin C are not indicated for use in the pediatric population.

Warnings and precautions

Hypersensitivity reactions: Acetylsalicylic acid and other NSAIDs can cause hypersensitivity reactions (including asthma attacks, rhinitis, angioedema, or urticaria). The risk is greater in subjects who have already experienced a hypersensitivity reaction after using this type of drug in the past and in subjects who have allergic reactions to other substances (e.g., skin reactions, itching, urticaria). In subjects with asthma and/or rhinitis (with or without nasal polyps) and/or urticaria, reactions may be more frequent and severe. In rare cases, reactions can be very serious and potentially fatal. In the following cases, administration of the drug requires a doctor's prescription after careful evaluation of the risk/benefit ratio: subjects at greater risk of hypersensitivity reactions; subjects at greater risk of gastrointestinal lesions; subjects habitually consuming large quantities of alcohol; subjects with coagulation disorders or treated with anticoagulants; subjects with impaired renal, cardiac, or hepatic function; subjects with asthma; geriatric age (especially over 75 years); aspirin should not be used in the pediatric population; subjects with hyperuricemia/gout; subjects with a predisposition to calcium-oxalate nephrolithiasis (kidney stones) or with recurrent nephrolithiasis.

Combination of drugs not recommended or requiring special precautions or dosage adjustment. The use of acetylsalicylic acid in combination with certain drugs can increase the risk of serious side effects. Do not use acetylsalicylic acid together with another NSAID or, in any case, do not use more than one NSAID at a time. Fertility: The use of acetylsalicylic acid, as with any drug that inhibits the synthesis of prostaglandins and cyclooxygenase, may interfere with fertility. Females, particularly women who have fertility problems or who are undergoing fertility investigations, must be informed of this. Sodium: Aspirin effervescent tablets with Vitamin C contain 933 mg of sodium per tablet: they may not be suitable for subjects on a low-sodium diet. If you are undergoing surgery (even minor, for example, tooth extraction) and have used acetylsalicylic acid or another NSAID in the previous few days, you must inform your surgeon due to the possible effects on coagulation. Since acetylsalicylic acid can cause gastrointestinal bleeding, this must be taken into account if occult blood testing is necessary.

Before administering any medicine, all necessary precautions must be taken to prevent adverse reactions. It is particularly important to rule out previous hypersensitivity reactions to this or other medicines and to rule out other contraindications or conditions that may expose you to the risk of potentially serious adverse effects listed above. If in doubt, consult your doctor or pharmacist.

Imperfect and prolonged storage of Aspirin C may cause changes in the colour of the tablet, which in itself does not affect the activity or tolerability of the active ingredient. In this case, it is advisable to ask your pharmacy to replace the pack. The product must be taken on a full stomach.

Interactions

Contraindicated combinations (avoid concomitant use): Methotrexate (doses greater than or equal to 15 mg/week), Warfarin. Not recommended combinations (the concomitant use of the two drugs requires a doctor's prescription after careful evaluation of the risk/benefit ratio): Antiplatelet drugs, Thrombolytics or oral or parenteral anticoagulants, NSAIDs (excluding topical use), Methotrexate (doses less than 15 mg/week), Selective Serotonin Reuptake Inhibitors (SSRIs). Combinations requiring special precautions or dosage adjustment (the concomitant use of the two drugs requires a doctor's prescription after careful evaluation of the risk/benefit ratio) ACE inhibitors, Valproic acid, Antacids, Antidiabetics (e.g. insulin and oral hypoglycemics), Digoxin, Diuretics, Acetazolamide, Phenytoin, Corticosteroids (excluding those for topical use and those used for the treatment of adrenocortical insufficiency), Uricosurics (e.g. probenecid, benzbromarone), Zafirlukast, Deferoxamine effervescent tablets with vitamin C, Alcohol. However, it is advisable not to administer other oral drugs within 1 or 2 hours of using the product.

Side effects

The most commonly observed side effects are: They frequently affect the gastrointestinal tract and may occur in approximately 4% of subjects taking acetylsalicylic acid as an analgesic-antipyretic. This percentage increases significantly in subjects at risk of gastrointestinal disorders. These disorders can be partially alleviated by taking the medicine on a full stomach. Most side effects are dependent on both the dose and duration of treatment. The side effects observed with acetylsalicylic acid are generally common to other NSAIDs. Blood and lymphatic system disorders. Prolonged bleeding time, anemia due to gastrointestinal bleeding, reduction in platelets (thrombocytopenia) in extremely rare cases. Following haemorrhage, a blood clot may be seen. Acute and chronic post-haemorrhagic/iron deficiency anaemia may occur (due, for example, to occult microhaemorrhages) with related alterations in laboratory parameters and related clinical signs and symptoms such as asthenia, pallor and hypoperfusion. Nervous system disorders Headache, dizziness. Rarely: Reye's syndrome. Rarely to very rarely: cerebral haemorrhage, especially in patients with uncontrolled hypertension and/or on anticoagulant therapy, which, in isolated cases, can be life-threatening. Ear and labyrinth disorders Tinnitus (buzzing/rustling/ringing/ringing in the ears) Respiratory, thoracic and mediastinal disorders Asthma syndrome, rhinitis (profuse rhinorrhea), nasal congestion (associated with hypersensitivity reactions). Epistaxis. Cardiac disorders. Cardiorespiratory distress (associated with hypersensitivity reactions). Eye disorders. Conjunctivitis (associated with hypersensitivity reactions). Gastrointestinal disorders. (Occult) gastrointestinal bleeding, upset stomach, heartburn, gastrointestinal pain, bleeding gums. Vomiting, diarrhoea, nausea, crampy abdominal pain (associated with hypersensitivity reactions). Rarely: gastrointestinal inflammation, gastrointestinal erosion, gastrointestinal ulceration, haematemesis (vomiting blood or coffee-ground material), melaena (passage of black, tarry stools), oesophagitis. Very rarely: haemorrhagic gastrointestinal ulcer and/or gastrointestinal perforation with associated clinical signs and symptoms and laboratory changes. Hepatobiliary disorders. Rarely: hepatotoxicity (usually mild and asymptomatic hepatocellular injury) manifested by increased transaminases. Skin and subcutaneous tissue disorders. Rash, edema, urticaria, pruritus, erythema, angioedema (associated with hypersensitivity reactions). Renal and urinary disorders. Altered renal function (in the presence of altered renal haemodynamic conditions), urogenital bleeding. General disorders and administration site conditions. Perioperative haemorrhages, haematomas. Immune system disorders. Rarely: anaphylactic shock with associated alterations in laboratory parameters and clinical manifestations.

Reporting suspected adverse reactions that occur after authorisation of the medicinal product is important, as it allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals are asked to report any suspected adverse reactions via the national reporting system of the Italian Medicines Agency. Website: http://www.agenziafarmaco.gov.it/it/responsabili.

Pregnancy and breastfeeding

Fertility. The use of acetylsalicylic acid, as with any drug that inhibits the synthesis of prostaglandins and cyclooxygenase, may interfere with fertility. Female subjects, particularly women who have fertility problems or who are undergoing fertility investigations, must be informed of this.

Pregnancy Inhibition of prostaglandin synthesis may adversely affect pregnancy and/or embryo/fetal development. Results of epidemiological studies suggest an increased risk of miscarriage and cardiac malformation and gastroschisis after the use of a prostaglandin synthesis inhibitor in early pregnancy. The absolute risk of cardiac malformations was increased from less than 1% to approximately 1.5%. The risk was estimated to increase with dose and duration of therapy. In animals, administration of prostaglandin synthesis inhibitors has been shown to result in increased pre- and post-implantation loss and embryo-fetal mortality. Furthermore, an increased incidence of various malformations, including cardiovascular, has been reported in animals administered prostaglandin synthesis inhibitors during the organogenetic period. During the first and second trimesters of pregnancy, acetylsalicylic acid should not be administered unless clearly necessary. If drugs containing acetylsalicylic acid are used by a woman attempting to conceive, or during the first and second trimesters of pregnancy, treatment should be as short as possible and the dose as low as possible. During the third trimester of pregnancy, all prostaglandin synthesis inhibitors may expose: the fetus to: cardiopulmonary toxicity (with premature closure of the ductus arteriosus and pulmonary hypertension), renal dysfunction, which may progress to renal failure with oligo-hydroamniosis, the mother and the unborn child, at the end of pregnancy, to: possible prolongation of bleeding time, an antiplatelet effect that may occur even at very low doses, inhibition of uterine contractions resulting in delayed or prolonged labor. Consequently, acetylsalicylic acid is contraindicated during the third trimester of pregnancy.

Breastfeeding. are contraindicated during breastfeeding.